In order to explain how Duphaston is used for endometrial hyperplasia, this article will first consider the concepts of endometrium and hyperplasia. Then methods of its treatment are described, and in detail - the use of Duphaston.

Endometrium and hyperplasia

The cavity of a woman is covered with a mucous layer of the endometrium. Its condition changes during the menstrual cycle. During the second phase of this cycle, the endometrium inside the uterus becomes larger, blood circulation increases. This provides the necessary conditions for the life of the embryo. If fertilization does not occur, then part of the endometrium during menstruation is excreted by the body.

One complication can be too much tissue enlargement in the uterus when the amount of endometrium grows. This disease is called endometrial hyperplasia, it can occur in women of all ages, and lead to various unpleasant consequences. In particular, endometrial hyperplasia can contribute to the development of cancer.

Causes of endometrial hyperplasia

Factors that affect changes in hormonal levels for the worse, thereby causing the appearance of endometrial hyperplasia:

• surgery;
• genital infection;
• too high blood sugar;
• inflammation of the genitals;
• puberty;
• obesity;
• heredity.

Only an examination carried out by a doctor can reveal the real cause of the disease in each specific case.

Endometrial hyperplasia symptoms

At first, hyperplasia does not make itself felt, so it is difficult to seek the help of a specialist in a timely manner. There are a number of symptoms that can occur with hyperplasia:

1. groin pain;
2. discharge between periods;
3. lack of pregnancy, despite sexual activity;
4. delayed menstruation, and then discharge exceeding the norm.

Varieties of endometrial hyperplasia

Hyperplasia is classified according to its structure:

1. Focal. The fabric in this form is thickened unevenly. Active multiplication of cells is also uneven, in some areas it is more significant. Focal hyperplasia, in turn, is subdivided into two types:

• simple - characterized by an increase in cell volume;
• complex - foci with excess tissue, are the cause of polyps.

1. Glandular cystic. In this case, the endometrial layer increases evenly. The mildest form of the disease - glandular hyperplasia - is characterized only by an increase in glandular tissue. But if the formation of bubbles with air is observed in the same case, then there is a glandular-cystic type of hyperplasia, a more severe variant of the disease;

1. Atypical. Also called adenomatosis. This is the most dangerous type of disease, the likelihood of developing oncology is high. With adenomatosis, cells multiply rapidly, increasing the amount of tissue, but they also change their structure, mutating. All this can cause the removal of the uterus;

1. IN . With age, the activity of the ovaries decreases, the body is rebuilt and there is a hormonal imbalance. It also leads to endometrial hyperplasia.

Endometrial thickness indicators

To diagnose hyperplasia, ultrasound is used, which allows you to establish the thickness of the endometrium. This sign determines the presence and type of hyperplasia.

Normal thickness is 9 to 11 mm. When the thickness exceeds the norm, in the range of 15-20 mm, this indicates glandular hyperplasia. If the thickness exceeds 20 mm, then a malignant tumor may be present.

Endometrial hyperplasia treatment

If the disease has not gone far, then treatment is possible, without scraping out excess tissue, with the help of medicines. Also, drug treatment is used if the patient is in adolescence, and if the possibility of developing adenomatosis is excluded.

Treatment of endometrial hyperplasia with Dufaston

First, the hormonal balance, upset by progesterone deficiency, is normalized. Typical hyperplasia is treated with gestagens, which regulate the reproductive system.

One of these drugs is (dydrogesterone).

What is Duphaston

Duphaston is an analogue of progesterone, a natural hormone. It is used if the hyperplasia is not atypical and is suitable for women of childbearing and older age. Duphaston contains dydrogesterone, a very safe and easily tolerated artificial progestogen. Its action is selective, directed at the endometrium. Therefore, the possible side effects are very minor.

List of possible unpleasant side effects:

• breast sensitivity increases;
• dizzy;
• in special cases, allergic reactions;
• bloody issues;
• chloasma.

The advantages of using Duphaston:

• lack of estrogenic effect;
• lack of corticosteroid effect;
• does not affect lipid metabolism;
• slightly affects the cardiovascular system;
• promotes conservation;
• does not affect blood clotting and sugar levels;
• does not affect the nervous system.

In the right doses, Duphaston effectively reduces estrogen-dependent endometrial growth. It is allowed to be taken by women with diabetes, obesity, kidney disease, varicose veins, thyroid disease, atherosclerosis.

The use of Duphaston in the treatment of endometrial hyperplasia

It is taken orally in the form of tablets containing 10 mg of dydrogesterone.

Reception and dosage of Duphaston is prescribed by a doctor. As a rule, at different ages, the reception is different:

1. reproductive age: one or two tablets (10 mg each) per day are taken from the 16th to the 25th day of the menstrual cycle or from the 5th to the 25th day - this preserves fertility and menstrual processes Reception can be carried out during pregnancy, but not during lactation;
2. age after 40-45 and up to 53-55 years: 1 tablet two or three times a day, on the same days of the cycle.

Usually the appointment lasts six months, in rare cases - nine months. The effectiveness of the course of treatment is checked by a doctor. He uses an ultrasound or biopsy every three months.

Contraindications

The use of Duphaston is contraindicated in women with congenital pathology (Rotor syndrome, Dabin-Johnson syndrome), as well as in case of allergy to the drug and individual intolerance.

Stages of treatment of endometrial hyperplasia with Dufaston

The process of treating hyperplasia is divided into four stages:

1. stopping bleeding;
2. hormone therapy;
3. cycle normalization;
4. systematic examination.

First step

At this stage, combined oral contraceptives are used, and if they do not help, then the patient is prescribed diagnostic curettage. Samples of the endometrium are taken from the uterine cavity. Hemostatic drugs are also administered. In some cases, it becomes necessary to use substances that replace blood and drugs that improve the water-salt balance. It is recommended to consume vitamins B and C.

Second phase

During the second stage, hormonal agents are used that do not allow the mucous layer of the uterus to thicken and grow. Duphaston is one such remedy, it increases the level, has a positive effect on the endometrium. It is efficiently and quickly absorbed into the bloodstream, and after a short period of time it is excreted in the urine. Its use is prescribed by a doctor and can only be purchased with a prescription. The prescription can be given by a gynecologist.

Stage three

At the third stage, ovulation is restored - having reached ovulation, the menstrual cycle can be restored. This is critical for patients of reproductive age, since pregnancy cannot occur without ovulation.

The pregnancy hormone - progesterone - is the substance, the deficiency of which provokes hyperplasia. Therefore, the normalization of the menstrual cycle and ovulation, equalize the hormonal background, eliminating the causes of the proliferation of uterine tissues.

Stage four

During this stage, a woman is examined by a gynecologist at least once every six months, undergoes examination and ultrasound examination. The thickness of the endometrium is measured, curettage can be performed. If necessary, continues to take oral contraceptives and vitamin complexes. All these measures are aimed at the timely diagnosis of complications and the prevention of relapses.

Menstruation with endometrial hyperplasia

One of the criteria by which you can determine the presence of the disease is. Every woman knows how she is, it usually goes away, and what kind of discharge is in a healthy state. Any deviation from the norm is a reason to pay attention and visit a gynecologist.

Endometrial hyperplasia and pregnancy

In pregnant women, this disease is much less common. And if it occurs, hyperplasia is usually focal type.

Endometrial hyperplasia and pregnancy

Many doctors do not recommend pregnancy if hyperplasia has already been detected. Because the presence of formations in the uterus, under the influence of pregnancy, threatens to turn into cancer. In addition, hyperplasia negatively affects the fetus itself, and leads to pathologies in its development.

After the glandular or focal forms of endometrial hyperplasia are cured, pregnancy occurs relatively easily. If there was atypical hyperplasia, then the risk of removing the uterus prevents pregnancy.

Here's what affects the ability to conceive after treatment:

• how neglected was the disease;
• what kind of hyperplasia took place;
• results of treatment;
• individual characteristics of the patient.

Prevention

At least twice a year, you should visit a gynecologist - this is the most reliable prevention. They also help prevent disease:

• timely treatment of hormonal disorders;
• the fight against excess weight;
• physical education;
• refusal - they increase the risk of pathologies;
• regular medical examination.

This medicine is an analogue of the natural hormone progesterone. It is used for therapy in gynecology with a lack of natural substances. The drug provides the proper therapeutic effect in a situation with hyperplasia of the uterine mucosa.

What is endometrial hyperplasia

This pathology is an estrogen-dependent enlargement of the endometrium. Hyperplasia is provoked by abnormal growth of mucosal cells, deformation, and then dysfunction of the uterine glands. With hyperplasia, the activity and structure of the mucosa are completely disturbed.

Endometrial hyperplasia therapy with Dufaston

The drug "closes" the endometrium, ensuring the retention of the ovum in it. When conception has not occurred, the portions of progesterone received from the outside inhibit the growth of the endometrium, due to which its rejection accelerates - menstruation begins.

What is good about Duphaston

The drug is an effective drug that does not cause side effects, like other drugs of early development with gestagens. The risk of developing unwanted actions is significantly reduced.

Indications and contraindications for use

When Duphaston is prescribed for the treatment of endometritis, only one condition is required - it is forbidden to decide for yourself when and how much to drink pills. A remedy is shown in such situations:

• chronic endometritis;
• past abortions;
• miscarriages due to endometrial pathology;
• infertility;
• hormonal deficiency;
• operations on the uterine appendages.

Contraindications:

• individual intolerance;
• identified allergy;
• congenital hepatic pathology: Rotor, Dabin-Johnson syndromes.

Composition and release forms

This medicine is available in tablet form for oral use. The drug is made on the basis of the active ingredient - dydrogesterone. It also contains additional components:

• lactose monohydrate;
• corn starch;
• colloidal suspension of silicon dioxide;
• magnesium stearate;
• titanium dioxide and polyethylene glycol.

The blister contains 20 tablets. Each package of the product contains detailed instructions regarding the rules for using the medication.

How to take Dufaston correctly

Therapy for hyperplasia of the endometrial layer is organized individually. It is recommended by a gynecologist, after performing a preliminary diagnostic curettage of the mucous membrane, and then conducting a histological examination of the samples obtained.

In reproductive age

• starting from the sixteenth and ending with the twenty-fifth day of the next menstrual cycle;
• starting with the fifth and ending with the twenty-fifth day of the next menstrual cycle.

Such prima regimens completely preserve menstrual function. Duphaston therapy is also allowed during pregnancy. But gynecologists do not recommend taking medicine for nursing mothers.

In climax

With the onset of menopause, therapy for endometrial pathology consists in the use of 2-3 tablets daily. With age adjustment, the natural reproductive function begins to fade away. The concentration of estrogen is significantly reduced, due to which the ovulation process stops, the egg ceases to leave the follicle.

The use of Duphaston with a thin endometrium

Side effects

The use of Duphaston sometimes provokes such side effects:

• migraine and dizziness;
• enlarged liver;
• nausea;
• swelling of the legs;
• itching of the epidermis;
• redness of the skin, the appearance of a rash.

Endometrial hyperplasia is a pathological condition in which an abnormal growth of the uterine layer occurs. The main reason for the beginning of this process is an imbalance of hormones: a lack of progesterone and an excessive concentration of estrogen. It is possible to suspend pathological changes with the help of medications that correct the hormonal background.

Norkolut and Duphaston with endometrial hyperplasia contribute to the normalization of progesterone levels, for this reason they are often used in the process of therapy.

It develops for various reasons and is diagnosed in women of any age. In this case, the glandular and fibrous tissues undergo a number of changes. This happens under the influence of the following factors:

• lack of the hormone progesterone, provoked by the individual characteristics of the body or hereditary predisposition;
• age-related hormonal changes (menopause and the onset of menopause);
• endocrine system pathology;
• recently performed surgical intervention in the organs of the reproductive system.

Therapy involves performing tasks such as:

• suppression of the pathological process;
• curing the disease;
• relief of pain syndrome;
• normalization of the menstrual cycle;
• prevention of the development of malignant tumors.

In the process of conservative therapy, hormonal medications are used. These can be oral contraceptives, gonadotropins, antiestrogens.

Development of pathologies

During the normal course of the menstrual cycle, under the influence of estrogen, the uterine layer changes. This is necessary in order to make it easier for the ovum to implant into it. The reproductive organ builds up the endometrium. It becomes thicker and looser, which improves blood circulation. If the oocyte does not fix, under the influence of progesterone, the functional layer is destroyed and leaves during the critical days.

In the case of successful implantation of the ovum, progesterone stimulates the full maturation of the endometrium. If a hormonal failure occurs in the body, the tissues of the reproductive organ begin to grow abnormally and do not collapse at the right time. As a result, there is a violation of the monthly cycle, excessive menstruation appears and is observed after a delay. Significant blood loss leads to the development of anemia, which is accompanied by dizziness and weakness. Often, at the beginning of the pathological process, it becomes impossible to become pregnant.

How Duphaston is used

Therapy aimed at eliminating hormonal deficiency must be competent and justified. Duphaston should be taken with hyperplasia strictly according to the doctor's prescription. The treatment regimen is selected on an individual basis, taking into account the need to preserve reproductive function. In combination with this remedy, suppositories, which are inserted into the vagina, and medications with a systemic effect can be used.

Treatment with Duphaston involves taking the drug from the 16th to the 25th day of the cycle. In some cases, 1-2 tablets are taken daily from the 5th to the 25th day.

If the pathology is diagnosed in women during menopause, the daily dose is 2-3 tablets. They are taken from the 5th to the 25th day of the cycle or from the 16th to the 25th.

During the period of age adjustment, the reproductive function fades away. The concentration of estrogen gradually decreases, the release of the egg from the follicle becomes impossible. The corpus luteum develops incompletely, respectively, progesterone begins to be produced in a smaller amount. Moreover, even an insignificant concentration of estrogen can lead to pathological changes in the layers of the genital organ. This is the reason for the need for hormone therapy.

The duration of the course of treatment varies from six months to nine months. Every three months, a series of examinations is carried out, according to the results of which the doctor decides on the advisability of further treatment with the use of this drug.

Indications and contraindications for use

Treatment with Duphaston is indicated in the following cases:

• endometriosis and various problems with the layer of the genital organ, including hyperplasia;
• infertility, which has arisen due to insufficient concentration of luteins;
• the threat of miscarriage or frequent spontaneous abortions triggered by a deficiency of progesterone;
• dysmenorrhea;
• secondary amenorrhea;
• dysfunctional uterine bleeding.

Despite the high effectiveness of the drug, in some cases it is contraindicated to take it. Among the contraindications are the following:

• liver pathology;
• allergy to active and auxiliary components;
• tendency to itching of the skin;
• excessive body weight.

First step

Once HPE therapy has been started, it is imperative to stop the menstrual cycle. Accordingly, they resort to prescribing oral contraceptives. If the woman's condition does not improve, then it is carried out for the purpose of carrying out diagnostic measures. In this case, tissue samples are taken for subsequent histological examination.

Bloody discharge is eliminated by using hemostatic agents. It is recommended to take pain relievers for pain. In some cases, therapy includes blood substitutes, drugs that help normalize the water-salt balance, and vitamin complexes.

They can take on an unusual nature, therefore, it is recommended to read additional information on this issue.

Second phase

After stopping bleeding, the second stage of therapy for endometrial hyperplasia begins. In this case, hormonal drugs are used that prevent the thickening and abnormal growth of the endometrium in the uterus.

Due to the intake of Duphaston, the concentration of progesterone increases. This has a positive effect on the condition of the genital organ. The drug is taken three times a day. A single dosage is 10 mg. Therapy with its use begins on the 5th day of the cycle, and ends on the 25th day.

If the development of the disease is observed in combination with disorders in the endocrine system, then they resort to additional prescription of drugs from the group of antagonists. Sedatives are taken in the case of the psychosomatic nature of the pathology. Thus, it is possible to eliminate the causes of inflammation and prevent further growth of the endometrium.

Stage three

At the next stage, the main task is to restore cyclicity. It is imperative that you ovulate regularly. Due to this, the cycle is completely restored, and the reproductive system begins to function normally. This point is extremely important in the treatment of hyperplasia.

Duphaston helps to normalize hormone levels, due to which ovulation appears.

Stage four

Due to the fact that the estrogenic effect has been eliminated, the reproductive function is restored, the pathological process is suspended. After ovulation, progesterone begins to be produced intensively, which is necessary for the normal course of the menstrual cycle.

Hyperplasia can lead to female infertility. Therefore, after the end of the main therapeutic measures, it is recommended to undergo an examination and ultrasound examination at least once every six months, measure the thickness of the uterine layer and, if necessary, perform curettage. During this period, oral contraceptives may also be prescribed. It should be borne in mind that often their components provoke side effects. The selection of medicines in this group is carried out exclusively by a doctor.

Dufaston's analogs

Norkolut has a similar effect with Duphaston . This drug helps to accelerate the breakdown of estrogen and thereby reduce the level of their concentration. At the same time, the amount of progesterone increases, and the abnormal growth of endometrial cells stops.

Norkolut therapy is carried out according to an individual scheme. Often, in combination with it, antibiotics, immunomodulatory agents and vitamin complexes are prescribed. When hyperplasia is detected, the courses of treatment are short and vary from 7 to 14 days. The daily dosage is only 1-2 tablets. After the uterine bleeding decreases, the medication is not stopped. For preventive purposes, it is used on certain days of menstruation.

As a rule, you need to drink pills from the 15th to the 25th day of the cycle. The doctor should adjust the dosage, choose the start and end dates of therapy.

Possible side effects:

• the beginning of hair growth in areas of the skin that were previously free of hair;
• hair loss in the temple area;
• acne on the chin, wings of the nose and forehead;
• oily skin, provoked by the intense activity of the sebaceous glands;
• sharp weight gain.

There are a number of contraindications to the use of Norkolut. Its reception is strictly prohibited in the following cases:

• neoplasms with suspected onset of a malignant process;
• puberty;
• allergy to the components of the medication.

• period of pregnancy;
• a history of liver pathologies;
• blood loss of unexplained etiology;
• renal failure;
• increased blood clotting;
• diabetes;
• high blood pressure.

Before starting therapy with Norkolut, a comprehensive examination is carried out, including an examination on a gynecological chair, an assessment of the condition of the mammary glands and tests to determine the level of hormones. When a woman is in a depressed state, the drug should be taken with extreme caution. If the desired effect is not achieved, then therapy using this agent is discontinued.

One of the important stages in the treatment of uterine layer hyperplasia is hormone therapy. Often, drugs such as Dufaston and Norkolut are prescribed. These medicines are able to normalize the level of hormones in a short time and thereby stop the pathological proliferation of the endometrium. Nevertheless, it is strictly forbidden to independently decide on the use of these funds. Only a doctor should prescribe them and select a dosage.

Collapse

Endometrial hyperplasia in premenopausal women is quite common. Premenopause is the intermediate period between childbearing age and the onset of menopause. The woman's ovaries and the production of female hormones are dying out. The predominant hormone is estrogen, which is responsible for the formation of the epithelium lining the uterine cavity.

With a normal menstrual cycle, the endometrium of the uterus is renewed monthly. But with the onset of premenopause, the detachment of the old layer of the endometrium is absent or is incomplete. This deficiency can cause the formation of endometrial hyperplasia and its degeneration into a malignant tumor.

How does endometrial hyperplasia manifest in premenopause?

Endometrial hyperplasia in premenopause is manifested depending on the individual characteristics of the pathology. But there are general symptoms of endometrial hyperplasia during the period of restructuring of the female body.

1. Bloody discharge appears that is not associated with the menstrual cycle. Violations of the schedule of critical days. The difference between the cycles can be 3-4 months. A delay in menstruation can suddenly be replaced by profuse bleeding, accompanied by severe pain and poor health.
2. Metabolic disease. Noticeable weight gain, increased male body hair, sweating.
3. Miscarriages and lack of pregnancy.
4. The appearance of pain and blood during and after intercourse.

With endometrial hyperplasia in premenopausal women, diseases such as mastopathy, uterine myoma are often present. Inflammatory processes become more frequent.

Symptoms

One of the main symptoms is menstruation. Discharge can be either scanty or copious with the appearance of large blood clots. Such a manifestation suggests that the epithelium of the uterine cavity was formed in an uneven layer. When the epithelium leaves in thin areas, menstruation passes with smearing, small secretions. Sometimes there are no signs of menstruation at all.

If a section of the thick endometrium is rejected, the woman develops abundant, clotted, bleeding. Such changes are very dangerous to health, as they signal serious pathological processes of the reproductive system.

Not infrequently, after heavy bleeding, anemia is formed, which is eliminated with iron preparations.

Diagnostics

Diagnosis of pathology during premenopause is carried out by a gynecologist. The specialist examines the patient on the gynecological chair, after which he decides on a further examination.

To carry out a complete diagnosis, the following methods can be used:

1. Genital ultrasound, as well as transvaginal ultrasound. With the help of a special sensor, which is placed inside the vagina or on the abdomen, the specialist measures the size of the endometrium, examines the uterine cavity for the presence of other formations (fibroids, fibroids, cysts).
2. Hysteroscopy. The procedure involves the collection of a small amount of epithelium for histological analysis. It is prescribed only if the endometrium is more than 6 mm thick.
3. Hormonal research. Venous blood is donated and the content of important hormones for the functioning of the female reproductive system is established.

Endometrial hyperplasia in premenopausal women can only be detected by an experienced specialist. It is impossible to independently determine the type of disease and the stage of its development.

Treatment

Treatment of glandular hyperplasia of the endometrium can be carried out using drug therapy. It is necessary to minimize the excess hormone estrogen, which, despite the dying period of the menstrual cycle, continues to produce layers of the uterine epithelium.

If the expected improvements have not occurred, then surgical curettage of the epithelium is used. Timely intervention of the surgeon will prevent the development of uterine cancer.

The most common method is uterine curettage. During the procedure, the specialist removes one or more layers of the epithelium, removes all excess growths and formations. The operation is performed under general anesthesia for 30-40 minutes. After the cleaning and recovery period, the woman is individually selected antibiotics to prevent inflammation.

Scraping procedure

Duphaston with endometrial hyperplasia

Premenopause sooner or later occurs in the life of every woman. The approximate age at which they enter this period is from 40 to 50 years. In order to make it easier for a woman to experience a frequent change in hormonal levels, she is prescribed special drugs.

The hormonal drug Duphaston helps to reduce estrogen, the production of progesterone. The drug is perfect for long-term use. Duphaston with endometrial hyperplasia stimulates the maintenance of the natural balance of hormones. Over time, pain disappears, the menstrual cycle stabilizes.

Only a doctor should diagnose and treat. Hormone therapy requires careful selection to exclude the occurrence of complications, to stimulate the growth of excess epithelium. If you treat the pathology yourself, you can provoke even more serious hormonal disorders. This will lead to the formation of irreversible processes in the body.

Endometriosis and endometrial hyperplasia refer to the hyperplastic processes of the female reproductive system. The incidence of these pathologies is very high - every quadruple woman has signs of hyperplastic diseases. Almost all of them have problems with conception.

The treatment of these diseases is always carried out in a comprehensive manner and in several stages. The main goal of therapy for hyperplasia and endometriosis is to normalize the hormonal balance in the woman's body. For this, hormonal agents are used.

Brief description of the drug

Utrozhestan is a hormonal herbal preparation. The main active ingredient of this drug is progesterone, which is a corpus luteum hormone.

Also in the composition of Utrozhestan there are auxiliary substances:

• Gelatin - part of an absorbable capsule;
• Peanut butter - the main filler of the capsule, in which the active ingredient is evenly distributed;
• Titanium dioxide - is a stabilizer of constituent substances;
• Soy lecithin;
• Glycerol.

Thanks to modern medical technologies, it became possible to make micronized forms of active ingredients in preparations, which include Utrozhestan. This allows the drug to be absorbed faster into the woman's bloodstream and delivered to target organs.

Utrozhestan is produced in yellowish soft capsules containing 100 mg or 200 mg of progesterone.

Influence of Utrozhestan on endometriosis

Endometriosis is a disease in which the cells of the inner layer of the wall of the uterus (endometrium) grow and function. The causes of this disease are still not fully understood. It is assumed that the occurrence of endometriosis is associated with the flow of menstrual blood into the abdominal cavity through the fallopian tubes.

The main effect of the use of Utrozhestan in this disease is associated with inhibition of the production of pituitary hormones. These include:

• Luteinizing hormone (LH);
• Follicle-stimulating hormone (FSH).

The purpose of treatment with Utrozhestan is to suppress the action of the above hormones on the tissues of the female reproductive system, in which there are endometrioid foci.

This leads to atrophy of endometrial cells located in an atypical place for them. The consequence of this is a decrease in pain during menstruation and a significant decrease in the amount of blood secreted.

However, hormonal treatment using progesterone is not the only and main treatment for this disease. Utrozhestan for endometriosis is used in combination with other drugs to eliminate the clinical symptoms of the disease.

Effects of Utrozhestan with hyperplasia

Endometrial hyperplasia is an enlargement of the inner wall of the uterine cavity, which occurs due to the excessive activity of the hormone estrogen. To suppress the production of this hormone, progesterone preparations are used, to which Utrozhestan belongs.

With endometrial hyperplasia, progesterone preparations stop the growth of the endometrium and significantly reduce its thickness. Utrozhestan is prescribed from the 14th day of the menstrual cycle, that is, from the moment of ovulation.

The main purpose of prescribing this drug for hyperplasia is that it contributes to the normal full-fledged rejection of the endometrium during menstruation.

After undergoing a course of progesterone therapy, a control examination using hysteroscopy on the 5-7 day of the cycle is necessary. The complete rejection of the inner layer of the uterine wall and a decrease in its thickness is considered a positive effect of treatment.

How to take Utrozhestan for treatment?

The drug can be taken in two ways:

• Orally (inside);
• Intravaginally (in the vagina).

The daily dose is 200-400 mg and is divided into 2 doses (morning and evening). In the early stages of the development of the disease, only intravaginal use is sufficient. If the disease is widespread in the female reproductive organs, then Utrozhestan must be taken inside.

Orally, the capsules should be taken whole, without chewing and drinking plenty of room temperature water.

The duration of Utrozhestan's use depends on the clinic of the disease and is set individually by the attending physician. Usually it is at least two weeks. Cancellation of the drug should be gradual, with a gradual decrease in the daily dose. The attending physician tells the patient about this even before starting the use of Utrozhestan.

Contraindications for admission

There are situations when Utrozhestan cannot be used for endometriosis and endometrial hyperplasia:

• Vaginal bleeding, the cause of which has not been established;
• Malignant neoplasms of the female reproductive system or mammary glands (including severe forms of mastopathy);
• Renal or hepatic impairment;
• Tendency to the formation of venous blood clots (thrombophlebitis, varicose veins of various localization);
• Incomplete miscarriage;
• Individual intolerance to the components of the drug.

You should also use Utrozhestan with caution in the following diseases: diabetes mellitus, heart and vascular diseases, epilepsy, bronchial asthma, migraine.

You should inform your doctor about all concomitant diseases in advance, so that no serious side effects on the body occur after taking Utrozhestan.