Which pills to switch from lindinet 20. Birth control pills lindinet

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Attention! The information presented in the article is for informational purposes only. The materials of the article do not call for self-treatment. Only a qualified doctor can diagnose and give recommendations for treatment based on the individual characteristics of a particular patient.

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Can your period start when you take Lindinet 20 or 30? What is the difference between drugs, which is better? I will consider for you the answers to these questions today.

If we talk about the onset of menstruation, then it can occur in that situation if a woman has violated the so-called cyclic use of this contraceptive pharmaceutical. In addition, diseases of the genital tract can be the cause of bleeding. In this situation, you need to see a doctor.

Pharmacological action and the difference between Lindinet 20 and Lindinet 30

Lindinet is a monophasic oral contraceptive that comes in prescription pills. The drug contains the active compound ethinyl estradiol, its dosage in drugs is different, from which the name of the drug Lindinet 20 and Lindinet 30 comes, which indicates the amount of active compound in 20 μg and 30 μg, this, in fact, is the main difference in these drugs.

The drug has a depressing effect on the secretion of gonadotropic hormones. The estrogenic component ethinyl estradiol of synthetic origin is involved in the regulation of the so-called menstrual cycle. There is also a gestagenic component in the product, represented by gestodene, which is also considered an active substance. In general, the medication interferes with the fertilization of the egg.

In addition, the susceptibility of the endometrium to the so-called blastocyst decreases. With regular intake, these pharmaceuticals also have a therapeutic effect, in a woman, by normalizing the menstrual cycle, the likelihood of gynecological inflammatory diseases decreases.

After oral administration, both drugs are absorbed from the gastrointestinal tract. The drug has a high bioavailability, almost reaching 99%. The pharmaceutical agent is biotransformed in the so-called liver cells. The drug is excreted by 60% by the kidneys, and by 40% it leaves the body through the intestines.

Application of Lindinet

Prescribe the medicine Lindinet one tablet per day for 21 days, it is advisable to use the medicine at the same time of the day. After the last pills have been used, it is necessary to take a seven-day break, during this period the so-called withdrawal bleeding occurs.

After a week's break, the medication is used again. Reception of the first pharmaceutical product begins from the first to the fifth day of the so-called menstrual cycle. If you skip taking a tablet form, it is recommended to use the missed tablet as soon as possible. If the interval in taking the pills is less than twelve hours, then the contraceptive effect of the drug is not reduced.

Indications for use

Contraceptive pharmaceuticals.

Contraindications for use

I will list when the contraceptive medicine is not used:

The presence of migraines with neurological symptoms;
- Venous thromboembolism;
- Pancreatitis;
- Lactation;
- Surgical intervention with prolonged immobilization;
- Diabetes;
- Pregnancy;
- With diagnosed cholestatic jaundice;
- With liver tumors;
- With prolonged use of glucocorticosteroids;
- Do not use a contraceptive for cholelithiasis;
- With Rotor syndrome;
- With hormone-dependent malignant processes;
- When vaginal bleeding is detected;
- Do not prescribe a contraceptive drug for severe itching;
- With otosclerosis;
- With vaginal bleeding of not clear origin;
- When smoking more than 15 cigarettes per day.

Do not prescribe a medicine if hypersensitivity to the components of this medicinal pharmaceutical is detected.

Side effects

The contraceptive pharmaceutical product causes some side effects, and they occur when using both Lindinet 20 and when prescribing Lindinet 30. These include: arterial hypertension, thromboembolism is observed, hearing loss occurs, hemolytic-uremic syndrome is noted, porphyria is characteristic, in addition, exacerbation systemic lupus erythematosus, acyclic bleeding is possible, amenorrhea may join.

Other negative manifestations will be as follows: vaginal dryness, candidiasis, hyperglycemia joins, there is soreness of the mammary glands, nausea and vomiting are characteristic, erythema nodosum joins, galactorrhea is fixed, soreness in the epigastrium, skin rash, chloasma, increased hair loss occurs, headache is observed , fluid retention, allergic reactions are noted, resistance to carbohydrates decreases.

Lindinet 20 is better or Lindinet 30?

It is impossible to say unequivocally which drug is better, since they are similar in their action, the difference is only in the amount of the active ingredient. Lindinet 20, like Lindinet 30, perfectly regulates the menstrual cycle, reduces the soreness of menstruation, but sometimes it can cause a slight increase in body weight.

In addition, Lindinet helps with skin problems, in particular, the face is cleared of acne, blackheads disappear, the skin becomes less oily. In general, this medication is inexpensive when compared to other contraceptive pill forms. It costs about 400 to 450 rubles.

Conclusion

What kind of drug to choose for use should be decided by the doctor gynecologist. It is strongly discouraged to use contraceptive pills at your own discretion, as you can harm the body.

Lindinet 20 (ethinyl estradiol + gestodene) is a monophasic tablet combination (estrogen + progestogen) contraceptive. Manufacturer - Hungarian pharmaceutical company "Gedeon Richter". Date of entry into the world market - 2004. The drug is valued for its ability to provide reliable contraception and effectively control the menstrual cycle. Lipndinet 20 is well tolerated, does not affect blood pressure and aldosterone concentration, which is especially important for women in the premenopausal and climacteric periods. Lindinet 20 is an excellent choice for women of middle reproductive age (from 22 to 35 years old) who need long-term, reliable and safe contraception, as well as for girls who are just starting to use hormonal contraception. Despite the low quantitative content of active ingredients, the drug reliably controls the menstrual cycle and is guaranteed to eliminate the characteristic pain in the lower abdomen. Lindinet 20 is the best choice in cases where a woman has developed unwanted effects due to a high dose of an estrogenic or progestin component. Lindinet 20 contains in its composition a minimum dose of ethinylestradiol and progestogen (gestodene), which ensures a rapid drop in the concentration of estrogen in plasma. Gestodene is included in the drug at a dose that does not have clinically significant glucocorticoid activity, which helps maintain a stable body weight.

This is confirmed by studies of the drug, demonstrating the absence of a significant increase in body weight in women. Gestodene is one of the most potent and highly selective progestins on the pharmaceutical market today. Due to its high activity, this substance is used in low concentrations, in which it does not affect the metabolism of fats and carbohydrates and does not exhibit androgenic properties. In addition to contraceptive, the drug also has a therapeutic effect, preventing the development of a number of gynecological diseases, incl. tumor etiology.

Before using Lindinet 20, a woman must undergo a medical examination, including the collection of family and personal anamnestic data, blood pressure measurement, laboratory tests, and a gynecological examination. In the future, a similar examination, provided that the woman takes oral contraceptives, should be carried out at a frequency of 1 every six months. Before the start of contraceptive therapy with the use of hormonal contraceptives, all possible benefits and potential risks are weighed for each woman, after which the doctor together with the woman makes a joint decision on the choice of one or another method of contraception. If, after starting to take the drug, a woman has developed or worsened diseases of the circulatory system, cardiovascular diseases, epilepsy, diabetes mellitus, depression, then contraceptive therapy should be discontinued.

Pharmacology

Monophasic oral contraceptive. Inhibits the secretion of pituitary gonadotropic hormones. The contraceptive effect of the drug is associated with several mechanisms. The estrogenic component of the drug is ethinyl estradiol, a synthetic analogue of the follicular hormone estradiol, which, together with the corpus luteum hormone, participates in the regulation of the menstrual cycle. The gestagenic component is gestodene, a derivative of 19-nortestosterone, which surpasses in strength and selectivity of action not only the natural hormone of the corpus luteum progesterone, but also other synthetic gestagens (for example, levonorgestrel). Due to its high activity, gestodene is used in low dosages, in which it does not exhibit androgenic properties and has practically no effect on lipid and carbohydrate metabolism.

Along with the indicated central and peripheral mechanisms that prevent the maturation of an egg capable of fertilization, the contraceptive effect is due to a decrease in the susceptibility of the endometrium to the blastocyst, as well as an increase in the viscosity of the mucus in the cervix, which makes it relatively impassable for sperm. In addition to the contraceptive effect, the drug, when taken regularly, also has a therapeutic effect, normalizing the menstrual cycle and helping to prevent the development of a number of gynecological diseases, incl. tumor nature.

Pharmacokinetics

Gestoden

Suction

After oral administration, it is rapidly and completely absorbed from the gastrointestinal tract. After a single dose, C max is noted after 1 hour and is 2-4 ng / ml. Bioavailability is about 99%.

Distribution

Gestodene binds to albumin and sex hormone binding globulin (SHBG). 1-2% is in plasma in free form, 50-75% specifically binds to SHBG. An increase in the level of SHBG in the blood caused by ethinyl estradiol affects the level of gestodene: the fraction associated with SHBG increases, and the fraction associated with albumin decreases. Average V d - 0.7-1.4 l / kg. The pharmacokinetics of gestodene depends on the level of SHBG. The concentration of SHBG in the blood plasma under the action of estradiol increases 3 times. With daily intake, the concentration of gestodene in the blood plasma increases by 3-4 times and in the second half of the cycle it reaches a saturation state.

Metabolism and excretion

Gestodene is biotransformed in the liver. The average plasma clearance is 0.8-1 ml / min / kg. The serum gestodene level decreases in two phases. T 1/2 in β-phase - 12-20 hours. Gestodene is excreted only in the form of metabolites, 60% - with urine, 40% - with feces. T 1/2 metabolites - about 1 day.

Ethinylestradiol

Suction

After oral administration, ethinyl estradiol is absorbed quickly and almost completely. The average C max in serum is reached within 1-2 hours after administration and is 30-80 pg / ml. The absolute bioavailability due to presystemic conjugation and primary metabolism is about 60%.

Distribution

Completely (about 98.5%), but nonspecifically binds to albumin and induces an increase in the level of SHBG in the blood serum. Average V d - 5-18 l / kg.

C ss is established by 3-4 days of taking the drug, and it is 20% higher than after a single dose.

Metabolism

Undergoes aromatic hydroxylation to form hydroxylated and methylated metabolites, which are present in the form of free metabolites or in the form of conjugates (glucuronides and sulfates). The metabolic clearance from blood plasma is about 5-13 ml.

Withdrawal

Serum concentration decreases in two phases. T 1/2 in the β-phase - about 16-24 hours. Ethinylestradiol is excreted only in the form of metabolites, in a ratio of 2: 3 with urine and bile. T 1/2 metabolites - about 1 day.

Release form

Film-coated tablets of light yellow color, round, biconvex, both sides without inscriptions; at the fracture white or almost white with a light yellow edging.

Excipients: sodium calcium edetate - 0.065 mg, magnesium stearate - 0.2 mg, colloidal silicon dioxide - 0.275 mg, povidone - 1.7 mg, corn starch - 15.5 mg, lactose monohydrate - 37.165 mg.

Shell composition: quinoline yellow dye (D + C yellow No. 10) (E104) - 0.00135 mg, povidone - 0.171 mg, titanium dioxide - 0.46465 mg, macrogol 6000 - 2.23 mg, talc - 4.242 mg, calcium carbonate - 8.231 mg, sucrose - 19.66 mg.

21 pcs. - blisters (1) - cardboard packs.
21 pcs. - blisters (3) - cardboard packs.

Dosage

Assign 1 tablet / day for 21 days, if possible at the same time of day. After taking the last pill from the package, take a 7-day break, during which withdrawal bleeding occurs. The next day after a 7-day break (i.e. 4 weeks after taking the first tablet, on the same day of the week), the drug is resumed.

Taking the first tablet of Lindinet 20 should be started from the 1st to the 5th day of the menstrual cycle.

When switching to taking Lindinet 20 from another combined oral contraceptive, the first Lindinet 20 tablet should be taken after taking the last tablet from the package of another oral hormonal contraceptive, on the first day of withdrawal bleeding.

When switching to Lindinet 20 with drugs containing only gestagen ("mini-pills", injections, implant), when taking "mini-pills", Lindinet 20 can be taken on any day of the cycle, switch from using an implant to taking Lindinet 20 is possible the next day after the removal of the implant, when using injections - on the eve of the last injection. In these cases, additional methods of contraception should be used in the first 7 days.

After an abortion in the first trimester of pregnancy, you can start taking Lindinet 20 immediately after surgery. In this case, there is no need to use additional methods of contraception.

After childbirth or after an abortion in the II trimester of pregnancy, the drug can be taken on days 21-28. In these cases, additional methods of contraception must be used in the first 7 days. At a later start of taking the drug in the first 7 days, an additional, barrier method of contraception should be used. In the case when sexual intercourse took place before the start of contraception, before starting to take the drug, you should exclude pregnancy or postpone the start of taking until the first menstruation.

If you miss a pill, the missed pill should be taken as soon as possible. If the interval in taking the pills is less than 12 hours, then the contraceptive effect of the drug does not decrease, and in this case there is no need to use an additional method of contraception. The rest of the tablets should be taken at the usual time. If the interval is more than 12 hours, then the contraceptive effect of the drug may decrease. In such cases, you should not replenish the missed dose, continue taking the drug as usual, but in the next 7 days you need to use an additional method of contraception. If, at the same time, less than 7 tablets remain in the package, you should start taking the drug from the next package without interruption. In this case, withdrawal bleeding does not occur until the completion of taking the drug from the second package, but spotting or breakthrough bleeding may appear.

If withdrawal bleeding does not occur after the completion of taking the drug from the second package, then pregnancy should be excluded before continuing to take the drug.

If vomiting and / or diarrhea begins within 3-4 hours after taking the drug, a decrease in the contraceptive effect is possible. In such cases, you should follow the directions for skipping pills. If the patient does not want to deviate from the usual contraceptive regimen, the missed pills should be taken from a different package.

To speed up the onset of menstruation, you should reduce the break in taking the drug. The shorter the break, the more likely it is that breakthrough or spotting bleeding will occur while taking the tablets from the next pack (similar to cases with delayed menstruation).

To delay the onset of menstruation, the drug must be continued from a new package without a 7-day break. You can delay your period as long as necessary until the end of the last pill from the second pack. With a delay in menstruation, breakthrough or spotting bleeding may appear. Regular use of Lindinet 20 can be restored after the usual 7-day break.

Overdose

No severe symptoms have been described after taking the drug in high doses.

Symptoms: nausea, vomiting, in girls - bleeding from the vagina.

Treatment: symptomatic therapy is prescribed, there is no specific antidote.

Interaction

The contraceptive activity of Lindinet 20 decreases when taken simultaneously with ampicillin, tetracycline, rifampicin, barbiturates, primidone, carbamazepine, phenylbutazone, phenytoin, griseofulvin, topiramate, felbamate, oxcarbazepine. The contraceptive effect of oral contraceptives decreases with the use of these combinations, breakthrough bleeding and menstrual irregularities become more frequent. While taking Lindinet 20 with the above drugs, as well as within 7 days after completing the course of taking them, it is necessary to use additional non-hormonal (condom, spermicidal gels) methods of contraception. When using rifampicin, additional contraceptive methods should be used within 4 weeks after completion of the course.

When used simultaneously with Lindinet 20, any drug that increases gastrointestinal motility, reduces the absorption of active substances and their level in the blood plasma.

Sulfation of ethinyl estradiol occurs in the intestinal wall. Drugs that also undergo sulfation in the intestinal wall (including ascorbic acid) competitively inhibit the sulfation of ethinyl estradiol and thereby increase the bioavailability of ethinyl estradiol.

Inducers of microsomal liver enzymes reduce the level of ethinylestradiol in the blood plasma (rifampicin, barbiturates, phenylbutazone, phenytoin, griseofulvin, topiramate, hydantoin, felbamate, rifabutin, oscarbazepine).

Liver enzyme inhibitors (itraconazole, fluconazole) increase the level of ethinyl estradiol in the blood plasma.

Some antibiotics (ampicillin, tetracycline), interfering with the intrahepatic circulation of estrogen, reduce the level of ethinyl estradiol in plasma.

Ethinyl estradiol by inhibiting liver enzymes or accelerating conjugation (primarily glucuronidation) can affect the metabolism of other drugs (including cyclosporine, theophylline); the concentration of these drugs in blood plasma may increase or decrease.

With the simultaneous use of Lindinet 20 with St. John's wort preparations (including infusion), the concentration of active substances in the blood decreases, which can lead to breakthrough bleeding, pregnancy. The reason for this is the inducing effect of St. John's wort on liver enzymes, which continues for 2 more weeks after the completion of the course of taking St. John's wort. It is not recommended to prescribe this combination of drugs.

Ritonavir reduces the AUC of ethinyl estradiol by 41%. In this regard, during the use of ritonavir, a hormonal contraceptive with a higher content of ethinyl estradiol should be used or additional non-hormonal methods of contraception should be used.

It may be necessary to adjust the dosage regimen when using hypoglycemic agents, because oral contraceptives can decrease carbohydrate tolerance, increase the need for insulin or oral antidiabetic drugs.

Side effects

Side effects requiring drug withdrawal

From the side of the cardiovascular system: arterial hypertension; rarely - arterial and venous thromboembolism (including myocardial infarction, stroke, deep vein thrombosis of the lower extremities, pulmonary embolism); very rarely - arterial or venous thromboembolism of the hepatic, mesenteric, renal, retinal arteries and veins.

From the senses: hearing loss due to otosclerosis.

Others: hemolytic uremic syndrome, porphyria; rarely - exacerbation of reactive systemic lupus erythematosus; very rarely - Sydenham's chorea (disappearing after drug withdrawal).

Other side effects are more common but less severe. The feasibility of continuing to use the drug is decided individually after consulting a doctor, based on the benefit / risk ratio.

From the reproductive system: acyclic bleeding / spotting from the vagina, amenorrhea after discontinuation of the drug, changes in the state of vaginal mucus, development of inflammatory processes in the vagina, candidiasis, tension, pain, enlargement of the mammary glands, galactorrhea.

From the digestive system: epigastric pain, nausea, vomiting, Crohn's disease, ulcerative colitis, the onset or exacerbation of jaundice and / or itching associated with cholestasis, cholelithiasis, hepatitis, liver adenoma.

Dermatological reactions: erythema nodosum, exudative erythema, rash, chloasma, increased hair loss.

From the side of the central nervous system: headache, migraine, mood lability, depression.

From the senses: hearing loss, increased sensitivity of the cornea (when wearing contact lenses).

From the side of metabolism: fluid retention in the body, change (increase) in body weight, decreased tolerance to carbohydrates, hyperglycemia, increased TG levels.

Others: allergic reactions.

Indications

Contraception.

Contraindications

• the presence of severe and / or multiple risk factors for venous or arterial thrombosis (including complicated lesions of the valvular apparatus of the heart, atrial fibrillation, diseases of the vessels of the brain or coronary arteries, severe or moderate arterial hypertension with BP ≥ 160/100 mm Hg . st.);
• the presence or indication of a history of precursors of thrombosis (including transient ischemic attack, angina pectoris);
• migraine with focal neurological symptoms, incl. in the anamnesis;
• venous or arterial thrombosis / thromboembolism (including myocardial infarction, stroke, deep vein thrombosis of the leg, pulmonary embolism) currently or in history;
• a history of venous thromboembolism;
• surgical intervention with prolonged immobilization;
• diabetes mellitus (with angiopathy);
• pancreatitis (including in history), accompanied by severe hypertriglyceridemia;
• dyslipidemia;
• severe liver disease, cholestatic jaundice (including during pregnancy), hepatitis, incl. history (before the normalization of functional and laboratory parameters and within 3 months after their normalization);
• jaundice when taking GCS;
• gallstone disease at present or in history;
• gilbert's syndrome, Dubin-Johnson syndrome, Rotor syndrome;
• liver tumors (including a history);
• severe itching, otosclerosis, or its progression during a previous pregnancy or taking GCS;
• hormone-dependent malignant neoplasms of the genitals and mammary glands (including if they are suspected);
• vaginal bleeding of unknown etiology;
• smoking over the age of 35 (more than 15 cigarettes per day);
• pregnancy or suspicion of it;
• lactation period;
• hypersensitivity to drug components.

The drug should be prescribed with caution in conditions that increase the risk of developing venous or arterial thrombosis / thromboembolism: age over 35 years, smoking, hereditary predisposition to thrombosis (thrombosis, myocardial infarction or cerebrovascular accident at a young age in one of the closest relatives), hemolytic uremic syndrome, hereditary angioedema, liver disease, diseases that first appeared or worsened during pregnancy or against the background of previous intake of sex hormones (including porphyria, herpes of pregnant women, chorea / Sydenham's disease /, Sydenham's chorea, chloasma) , obesity (BMI over 30 kg / m 2), dyslipoproteinemia, arterial hypertension, migraine, epilepsy, valvular heart disease, atrial fibrillation, prolonged immobilization, major surgery, surgery on the lower extremities, severe trauma, varicose veins and superficial thrombophlebitis , postpartum period (n e lactating women / 21 days after childbirth /; lactating women after the end of the lactation period), the presence of severe depression (including in the history), changes in biochemical parameters (resistance of activated protein C, hyperhomocysteinemia, antithrombin III deficiency, protein C or S deficiency, antiphospholipid antibodies, including antibodies to cardiolipin, lupus anticoagulant), diabetes mellitus not complicated by vascular disorders, SLE, Crohn's disease, ulcerative colitis, sickle cell anemia, hypertriglyceridemia (including family history), acute and chronic liver diseases.

Application features

Application during pregnancy and lactation

The drug is contraindicated for use during pregnancy and lactation.

In small amounts, the components of the drug are excreted in breast milk.

When used during lactation, milk production may decrease.

Application for violations of liver function

Contraindicated in liver dysfunction.

Application for impaired renal function

The drug is not recommended for use in kidney disease.

special instructions

Before starting to use the drug, it is necessary to conduct a general medical (detailed family and personal history, blood pressure measurement, laboratory tests) and gynecological examination (including examination of the mammary glands, pelvic organs, cytological analysis of a cervical smear). A similar examination during the period of taking the drug is carried out regularly, every 6 months.

The drug is a reliable contraceptive: the Pearl index (an indicator of the number of pregnancies occurring during the use of a contraceptive method in 100 women within 1 year), when used correctly, is about 0.05. Due to the fact that the contraceptive effect of the drug from the start of administration is fully manifested by the 14th day, in the first 2 weeks of taking the drug, it is recommended to additionally use non-hormonal methods of contraception.

In each case, before the appointment of hormonal contraceptives, the advantages or possible negative effects of their use are individually assessed. This issue must be discussed with the patient, who, after receiving the necessary information, will make a final decision on the preference for hormonal or some other method of contraception.

The health status of a woman must be carefully monitored. If, while taking the drug, any of the following conditions / diseases appears or worsens, you must stop taking the drug and switch to another, non-hormonal method of contraception:

• diseases of the hemostatic system;
• conditions / diseases that predispose to the development of cardiovascular, renal failure;
• epilepsy;
• migraine;
• the risk of developing an estrogen-dependent tumor or estrogen-dependent gynecological diseases;
• diabetes mellitus, not complicated by vascular disorders;
• severe depression (if depression is associated with impaired tryptophan metabolism, then vitamin B 6 can be used for correction);
• sickle cell anemia; in some cases (for example, infections, hypoxia), estrogen-containing drugs for this pathology can provoke thromboembolism;
• the appearance of abnormalities in laboratory tests to assess liver function.

Thromboembolic diseases

Epidemiological studies have shown that there is a link between taking oral hormonal contraceptives and an increased risk of developing arterial and venous thromboembolic diseases (including myocardial infarction, stroke, deep vein thrombosis of the lower extremities, pulmonary embolism). An increased risk of venous thromboembolic diseases has been proven, but it is significantly less than during pregnancy (60 cases per 100 thousand pregnancies). When using oral contraceptives, arterial or venous thromboembolism of hepatic, mesenteric, renal or retinal vessels is very rarely observed.

The risk of arterial or venous thromboembolic disease increases:

• with age;
• when smoking (heavy smoking and age over 35 are risk factors);
• if you have a family history of thromboembolic disease (for example, in a parent, brother or sister). If you suspect a genetic predisposition, it is necessary to consult a specialist before using the drug;
• with obesity (BMI over 30 kg / m 2);
• with dyslipoproteinemia;
• with arterial hypertension;
• with diseases of the heart valves complicated by hemodynamic disorders;
• with atrial fibrillation;
• with diabetes mellitus complicated by vascular lesions;
• with prolonged immobilization, after major surgery, after surgery on the lower extremities, after severe trauma.

In these cases, it is assumed that the drug should be temporarily discontinued (no later than 4 weeks before surgery, and resume no earlier than 2 weeks after remobilization).

Postpartum women have an increased risk of venous thromboembolic disease.

It should be borne in mind that diabetes mellitus, systemic lupus erythematosus, hemolytic uremic syndrome, Crohn's disease, ulcerative colitis, sickle cell anemia, increase the risk of developing venous thromboembolic diseases.

It should be borne in mind that resistance to activated protein C, hyperhomocysteinemia, protein C and S deficiency, antithrombin III deficiency, the presence of antiphospholipid antibodies, increase the risk of developing arterial or venous thromboembolic diseases.

When assessing the benefit / risk ratio of taking the drug, it should be borne in mind that targeted treatment of this condition reduces the risk of thromboembolism. The symptoms of thromboembolism are:

• sudden chest pain that radiates to the left arm;
• sudden shortness of breath;
• any unusually severe headache that persists for a long time or appears for the first time, especially when combined with sudden complete or partial loss of vision or diplopia, aphasia, dizziness, collapse, focal epilepsy, weakness or severe numbness of half of the body, movement disorders, severe one-sided pain in the gastrocnemius muscle, acute abdomen symptom complex.

Tumor diseases

Some studies have reported an increased incidence of cervical cancer in women who have taken hormonal contraception for a long time, but research results are conflicting. Sexual behavior, human papillomavirus infection and other factors play a significant role in the development of cervical cancer.

A meta-analysis of 54 epidemiological studies showed that there is a relative increase in breast cancer risk among women taking oral hormonal contraceptives, but higher breast cancer detection rates may have been associated with more regular medical screening. Breast cancer is rare among women younger than 40 years old, whether they are taking hormonal contraception or not, and increases with age. Taking pills can be one of many risk factors. However, the woman should be made aware of the potential for breast cancer risk based on an assessment of the benefit / risk ratio (protection against ovarian and endometrial cancer).

There are few reports on the development of benign or malignant liver tumors in women taking hormonal contraceptives for a long time. This should be borne in mind in the differential diagnostic assessment of abdominal pain, which may be associated with an increase in liver size or intraperitoneal bleeding.

Chloasma can develop in women with a history of this disease during pregnancy. Those women who are at risk of chloasma should avoid contact with sunlight or ultraviolet radiation while taking Lindinet 20.

Efficiency

The effectiveness of the drug may decrease in the following cases: missed pills, vomiting and diarrhea, the simultaneous use of other drugs that reduce the effectiveness of contraceptive pills.

If the patient is simultaneously taking another drug that may reduce the effectiveness of birth control pills, additional methods of contraception should be used.

The effectiveness of the drug may decrease if, after several months of their use, irregular, smearing or breakthrough bleeding appears, in such cases it is advisable to continue taking the pills until they end in the next package. If at the end of the second cycle menstrual bleeding does not start or acyclic spotting does not stop, stop taking the pills and resume it only after excluding pregnancy.

Changes in laboratory parameters

Under the influence of oral contraceptive pills - due to the estrogenic component - the level of some laboratory parameters (functional parameters of the liver, kidneys, adrenal glands, thyroid gland, hemostasis indicators, levels of lipoproteins and transport proteins) may change.

Additional Information

After acute viral hepatitis, the drug should be taken after normalization of liver function (no earlier than 6 months).

With diarrhea or intestinal disorders, vomiting, the contraceptive effect may decrease. Without stopping taking the drug, you must use additional non-hormonal methods of contraception.

Women who smoke have an increased risk of developing vascular diseases with serious consequences (myocardial infarction, stroke). The risk depends on age (especially in women over 35) and on the number of cigarettes smoked.

A woman should be warned that the drug does not protect against HIV infection (AIDS) and other sexually transmitted diseases.

Influence on the ability to drive vehicles and use mechanisms

No studies have been conducted to study the effect of Lindinet 20 on the ability to drive a car and industrial machinery.

Latin name:Lindynette
ATX code: G03AA10
Active substance: Ethinylestradiol
Manufacturer:Gedeon Richter, Hungary
Pharmacy dispensing condition: On prescription

Lindinet 20 is a low hormone oral contraceptive.

Indications for use

Lindinet 20 tablets are taken for contraceptive purposes, as well as for the regulation of disturbed menstrual function.

Composition

One hormonal contraceptive tablet contains two main components, which are represented by ethinylestradiol and gestodene, their mass fraction is 0.02 mg and 0.075 mg, respectively.

Additionally, there are such substances:

• Povidone
• Magnesium stearate
• Corn starch
• Colloidal silicon dioxide
• Lactose monohydrate
• Sodium calcium edetate.

Healing properties

A contraceptive based on ethinylestradiol and gestodene inhibits the synthesis of gonadotropic hormones by the pituitary gland, which slows down the maturation of follicles.

The estrogen component of contraceptive pills is ethinyl estadiol, which is one of the synthetic analogs of the estradiol hormone produced in the human body, which is actively involved in the regulation of menstrual function along with progesterone.

Gestodene is the second component of the contraceptive, it is classified as a derivative of 19-nortestosterone, in terms of the strength of the effect, it significantly surpasses both the natural hormone, progesterone, and its synthetic analogue, levonorgestrel. Due to the fact that the activity of this progestogenic component of Lindinet is quite high, it will be used in low doses. Due to this, there is no significant effect on the course of metabolism of fats and carbohydrates, and its androgenic properties are not manifested.

The action of the contraceptive is associated with the work of both central and peripheral mechanisms that inhibit the process of follicle maturation, thereby reducing the susceptibility of the endometrial uterine layer to the blastocyst itself. This increases the viscosity of secretions (namely, cervical mucus), which significantly reduces the likelihood of conception.

If you drink Lindinet 20 constantly (as the description for the drug indicates), you can observe the therapeutic effect of the contraceptive - the MC normalizes, the risk of developing some gynecological ailments, including oncological ones, decreases.

Ethinylestradiol is almost completely absorbed by the gastrointestinal mucosa. After 1-2 after taking the pills (according to the instructions), its highest concentration in the blood is observed. The bioavailability index is 60%. The connection with albumin is 98.5%.

As a result of aromatic hydroxylation, methylated and hydroxylated metabolites are formed. The elimination process takes place with the participation of the renal system and intestines, the half-life is 24 hours. In this case, a stable level of ethinyl estradiol is recorded on 3-4 days.

Gestodene also quickly goes through the absorption process in the digestive tract, the highest levels of this substance in the blood are reached after 60 minutes. The bioavailability of the gestagenic component of the drug reaches 99%.

The amount of gestodene in the blood decreases slowly, the half-life of metabolic products is 24 hours. A stable level of gestodene is observed in the second half of the MC.

Release form

Hormonal pills are round, light cream shade, placed in a blister pack of 21 pcs. There can be 1 or 3 blisters inside the pack. packaging with instructions.

Lindinet 20: instructions for use

Price from 381 to 2059 rubles.

The hormonal drug Lindenet must be used at the same time every day to ensure their contraceptive effect. It is worth noting that Lindinet 30 is also accepted, the instructions for use are similar.

If the hormonal drug is used for the first time, then the first tablet is taken from 1 MC to 5 MC. It is necessary to take Lindinet 20 for 21 days, after which a seven-day withdrawal of the hormonal drug is provided, it is on these days that menstruation begins. Hormones from a new blister pack are started at 8 days. regardless of whether the withdrawal bleeding is completed or not.

Transfer from another COC

The Lindinet 20 tablet will need to be taken the next day after the woman took the last COC pill from the blister. The onset of the first period is normal.

Switching from mini-pills, hormonal injections, intrauterine systems or implants

The start of hormone therapy can be carried out on any day of the MC if you have taken mini-pills. When using earlier implants - on the day of removal, injection of hormones - on the day of the intended injection.

In the case of switching from mono-drugs, it will be necessary to use barrier contraceptive measures so that the woman does not become pregnant during the first cycle of administration.

After an early abortion (1 trimester)

Hormone therapy with birth control pills should begin on the same day the surgery is performed. Let the woman drink them according to the standard scheme, there is no need to protect herself, since in this case you will not get pregnant. After an abortion, long-term hormone therapy is indicated.

After an abortion at a later date (2nd trimester)

The first Lindinet 20 tablet should be taken after 28 days. (one month) without using any additional contraceptive measures. If you take the contraceptive drug later than the specified period, for 7 days. you should additionally protect yourself from pregnancy.

If, before taking contraceptives, a woman had unprotected sexual contacts, one should start using hormonal pills after excluding a possible pregnancy, or do it differently - take a Lindinet 20 pill for the first time directly on the first day of the MC (when your own menstrual cycle begins).

Scheme of admission when skipping pills

If you missed the use of pills, there is no need to cancel their intake, take the missed Lindinet 20 pill as soon as you remember about it.

If the gaps in taking the pills do not exceed 12 hours, then the contraceptive effect works, barrier protection measures are not used. All subsequent pills are taken as usual, skipping the drug does not affect the contraceptive effect.

If a woman has a chance to miss another contraceptive intake, and the time interval exceeds 12 hours, hormonal pills are not as effective. A woman should drink a pill that she missed, the subsequent ones are taken according to the standard scheme. Additionally, barrier methods of protection are used for 7 days. from the moment when there was a pass.

If there was a missed pill, and there are less than 7 pieces left in the package, it is best that the woman does not take a break in taking hormonal pills. Skipping pills in the third week of contraceptive therapy does not significantly reduce its effectiveness.

It should be borne in mind that if you take these contraceptives continuously, there will be no menstruation, but breakthrough vaginal bleeding may occur during the use of tablets from a new blister. If after two months of continuous pill intake (including the cycle when there was a skip) menstrual bleeding does not occur, it is imperative to exclude pregnancy when taking Lindinet 20. What to do next, consult your gynecologist, he will offer several solutions to the problem.

What to do if vomiting, diarrhea starts

If, taking the pills, vomiting or diarrhea is observed, and more than 3-4 hours have not passed since the moment of taking the drug, this can be compared with missing a pill, the likelihood of pregnancy increases. What to do - take the same steps as for the missed pill. If the woman does not want to change the contraceptive regimen, take the Lindinet 20 tablet from a new blister.

How to postpone your period

If, with prolonged use of a hormonal drug, it becomes necessary to delay your period, take hormonal pills without the usual seven-day break. You can postpone menstruation for any number of days, until the completion of the pills from the second blister. Do not exclude the possibility of spotting bleeding or breakthrough bleeding (such a reaction of the body is considered normal). After the end of the seven-day break, you can drink Lindinet 20 as usual. What to do if you need to finish taking Lindinet, consult with your gynecologist.

Use during pregnancy and hepatitis B

Hormone pills are not prescribed during pregnancy. If it becomes necessary to use a contraceptive during lactation, it is worth completing breastfeeding.

Contraindications

You should not take this hormonal remedy if:

• Excessive susceptibility to contraceptive constituents
• Pathologies caused by impaired liver function
• Pathological neoplasms in the liver
• Tendency to thrombosis, as well as thromboembolism
• Serious pathologies of CVS (including myocardial infarction)
• Sickle cell anemias
• The presence of estrogen-dependent neoplasms
• Uterine bleeding of unexplained origin
• Diabetes mellitus, which occurs against the background of microangiopathy
• Idiopathic jaundice
• Herpes manifestations
• Pregnancy
• Otosclerotic changes
• Over 35 years of age (since the likelihood of side effects increases significantly with age).

Precautions

Special care should be taken in the presence of such pathological conditions and diseases:

• Severe migraine headaches
• Oncological process in the mammary glands
• Frequent epileptic seizures
• Pathologies of the functioning of the gallbladder (including gallstone ailments)
• Increased blood pressure
• Immobilization
• Depressive state
• The recovery period after a major surgery
• Diabetes
• Cholestatic jaundice
• Various forms of liver failure.

If the patient's age is over 35 years old and she smokes, it is worth consulting with a specialist about the possibility of switching to Lindinet 30. It should be noted that the woman's age and the amount of hormones taken directly affects the contraceptive effect. After 40 years, it is worth choosing other means of contraception.

Cross-drug interactions

In accordance with the instructions for Lindient 20 and 30 inducers of hepatic microsomal enzymes, antibacterial drugs significantly reduce the level of estrogen in the blood, which increases the likelihood of pregnancy. Is it possible to get pregnant during this period? Yes, the probability is high enough. During the entire treatment period and over the next 7 days. upon its termination, it is necessary to resort to the use of additional contraceptive measures.

Inhibitors of liver enzymes, in turn, increase the concentration of estrogen components in the blood.

Drugs that increase gastrointestinal motility, reduce the absorption of components of hormonal pills.

Ascorbic acid slows down the process of sulfation of estrogen components, and increases their bioavailability.

The hormonal agent affects the metabolic processes of cyclosporine and theophylline in the body, which can cause an unforeseen reaction from various organs and systems.

Do not drink drugs with St. John's wort, as during phytotherapy, heavy menstruation (bleeding) can begin.

Patients with diabetes mellitus should adjust the dosage of hypoglycemic drugs taken.

It is worth noting that the same cross-talk occurs when the Lindinet 30 birth control pill is taken.

Side effects

While taking birth control pills, undesirable reactions may develop:

• CVS: very rarely, thromboembolism or thrombosis may develop against the background of increased blood clotting, a sharp jump in blood pressure
• Gastrointestinal tract: severe nausea and urge to vomit, the development of hepatocellular adenoma, possibly hepatitis
• Reproductive system: decreased libido, heavy periods, impaired secretion of vaginal discharge
• Endocrine system: changes in weight, feeling of tension in the chest
• Central nervous system: emotional instability, a tendency to depressive states (against the background of prolonged hormonal therapy), frequent headaches, lethargy, increased fatigue, migraine (very severe headache).

You can also observe: painful sensations in the lower abdomen, the occurrence of chloasma (with a tendency to exclude prolonged exposure to the sun), intolerance to contact lenses, swelling, manifestations of allergies, symptoms of impaired glucose tolerance. This reaction can develop as a result of prolonged use of hormones.

Overdose

If a woman drank higher dosages of the drug, the following symptoms may be observed: nausea and vomiting, headache. Overdose can manifest itself as heavy periods.

Symptomatic therapy is recommended. What to do - consult a doctor (he will advise you to cancel the drug) and drink the prescribed drugs. After this, there is a significant improvement in the general condition and the cessation of bleeding. It should be noted that there is no specific antidote.

Storage conditions and shelf life

Hormonal pills are stored at an average temperature not exceeding 30 C. The shelf life of the contraceptive is 3 years.

Analogs

Bayer Pharma, Germany

Price from 500 to 2142 rubles

Logest is similar in composition to Lindinet 20, it is a low-dose contraceptive. It is taken in the same way, it has similar contraindications, it can cause side effects similar to Lindinet. The pack contains 1 (21 tab.) Or 3 (63 tab.) Blist. packaging.

Pros:

• The pills work effectively (block the onset of ovulation)
• Regulates the MC
• It is used to treat some hormone-dependent gynecological diseases.

Minuses:

• High price
• High risk of side effects
• Not assigned if the woman is over 35 years old.

Which not only prevent unwanted pregnancy, but also have a pronounced healing property for gynecological diseases. One of these drugs is Lindinet 20 and 30 ... In this article, we will introduce you to the instructions, the method of application and other important points regarding these contraceptive pills. How to use Lindinet, a brief overview of the instructions Drink pills 1 time a day for 21 days... You need to drink it at the same time of day. daily. For example, you drank the first pill at 09:00, which means that all the following days you take the tablets at 09:00. When all the pills (21 pieces) have been drunk, arrange a seven-day break, during which bleeding should occur. Then, on the same day of the month when the first pill was taken (for example, on the 18th of January), the use of the drug resumes again (on the 18th of February). And so every month. The first contraceptive pill must be taken from the 1st to the 5th day of your period. In the case when there is a transition from one oral contraceptive (combined type) to Lindinet, the very first pill is drunk immediately on secondthe day after the end of taking the previous contraceptive. After abortion, held in the 1st trimester of pregnancy, Lindenet should be started on the second day or on the day after the operation. There is no need to resort to auxiliary methods of protection. But after an abortion done in the 2nd trimester, as well as after childbirth, the use of pills can be started no earlier than 21-28 days. In this case, additional methods of contraception will be required in the first 7 days. What is the difference between Lindinet 20 and Lindinet 30? Which pills are right for you, can only be prescribed by a doctor, based on tests. Lindinet 20 is more designed for young nulliparous girls. The content of hormones in it is less than in Lindinet 30 tablets. If you do not take into account the characteristics of the body of each particular woman, then if you are 20 years old, most likely the doctor will prescribe Lindinet 20, and accordingly after 30 years, he will write Lindinet 30. Features of taking Lindinet 20 and Lindinet 30 tablets When taking birth control pills Lindinet form 20 or 30, it must be borne in mind that if drugs such as ampicillin, tetracycline, felbamate, fluconazole are used, then the activity of the contraceptive decreases. Therefore, if you drink Lindinet with these medicines, take care of additional contraceptive measures, for example, based on spermicides, or any of the barrier methods. Also, St. John's wort tea lowers the level of Lindenet in the blood and can cause pregnancy or intermediate bleeding. Therefore, in the case of taking Lindenet 20 or Lindenet 30 in conjunction with other medications, you need to consult a doctor and make sure that they do not affect the decrease in the active substance of the contraceptive pill. It should be noted that the drug should not be taken during pregnancy, diabetes mellitus, lactation, venous insufficiency, for any disorders associated with the kidneys and liver. Side effects from taking Lindinet The individual characteristics of each woman impose their own side effects from taking Lindinet. In the event of one or more of the side effects indicated in the list below, the drug should be discontinued. These side effects include: 1. Violation of the cardiovascular system. It manifests itself in the form of arterial hypertension or thromboembolism. 2. Hearing loss. 3. Chorea of \u200b\u200bSindenhem. 4. Candidiasis. 5. Bleeding. 6. Galactorrhea. 7. Nausea and vomiting. 8. Breast enlargement and pain in it. 9. Hepatitis. 10. Rash. 11. Erythema nodosum. 12. Headache. 13. Depression. 14. Weight gain. 15. And other allergic reactions. If you experience any of the above after taking the Lindinet birth control pill, please tell your doctor immediately. What if I missed Lindinet's appointment? If for any reason the Lindinet 20 or 30 pill was missed, you should drink it as soon as possible. Less than 12 hours If the interval between taking the pills was no more than 12 hours, the contraceptive property of the drug will not decrease. You do not need to resort to additional contraception. Subsequent pills should be continued as usual. More than 12 hours When the interval between contraception is more than 12 hours, the effectiveness of the contraceptive may decrease. There is no need to take the missed dose. But during the week you will need to use additional contraceptives (condoms, suppositories) to avoid pregnancy. Menstruation when taking Lindinet Menstruation while taking Lindinet may occur if the cycle of using the contraceptive drug has been violated. But in any case, there was a failure in taking the pills or not, it is necessary to consult a gynecologist. The cause of bleeding during the use of Lindinet may be diseases of the genital tract. Therefore, you should immediately consult a doctor who, having made an examination, will be able to find out the true cause of the bleeding. Content Modern women protect themselves from unwanted pregnancies. Barrier methods such as condoms and hormonal pills are considered reliable methods of contraception. Of the popular oral drugs, Lindinet is distinguished. This medication contains a complex of hormones that prevent ovulation and slow down the penetration of sperm into the egg. What is Lindinet Lindinet birth control pills are part of the group of oral contraceptives based on sex hormones. Lindynette is produced by the Hungarian pharmaceutical company Gedeon Richter and contains ethinyl estradiol and gestodene as active ingredients. The complex effect of active ingredients changes the mechanism of secretion of gonadotropic hormones, inhibiting the maturation of follicles in the ovaries. pharmachologic effect A monophasic combination drug is used for contraception. Its action is associated with a decrease in the pituitary secretion of gonadotropins, preventing ovulatory processes (maturation of the egg). Ethinyl estradiol is a synthetic analogue of the follicular hormone estradiol, which, together with the hormones of the corpus luteum, takes part in the regulation of the menstrual cycle. Gestodene is a progestogenic derivative of nortestosterone and a synthetic progestin, has a strong selective effect compared to natural progesterone, whose secretion is regulated by the corpus luteum. This substance is used in a minimal amount, therefore it has little effect on the carbohydrate-lipid metabolism by enzymes. The drug directly affects sex hormones, but also acts through the peripheral centers. Under the influence of the medication, the susceptibility of the endometrium of the uterus to the blastocyst decreases, so fertilization does not occur, and the fetus cannot be implanted. The drug increases the density and viscosity of mucus in the cervix, making it difficult for the sperm to pass through. The estrogenic effect of the drug is also used for the active prevention of gynecological diseases, with dysfunction or deficiency of hormones of the gonads. The drug can reduce the risk of functional ovarian cysts in the vagina, ectopic pregnancy. While taking the tablets, the degree of acne manifestation decreases, hemostasis remains. Pharmacokinetic properties of the drug: Laboratory parameter Gestoden Ethinylestradiol Bioavailability of blood serum,% Time to reach maximum concentration, h Association with albumin and other proteins,% Metabolism Metabolite yield With urine and feces (intestines, kidneys) With urine and bile Withdrawal period, days What is the difference between Lindinet 20 and Lindinet 30 Contraceptives Lindinet have different dosages - 20 and 30 mcg ethinylestradiol. The drug with a dosage of 20 mcg is milder in pharmacological action, used for contraception, but not for therapeutic needs. A medication with a hormone level of 30 mcg per tablet can be used to protect against unwanted pregnancy, but the change in the load on the woman's hormonal system increases. Release form Both forms of Lindinet are presented in the form of round biconvex tablets covered with a light yellow film shell. There are no marks and marks on the surface, inside the tablet is white. The medicinal product is presented in cardboard boxes of 1 or 3 blisters inside with instructions for use. Each blister contains 21 tablets, based on the average menstrual cycle. Composition Depending on the form of release, only the concentration of hormones differs. The main composition of the tablets is similar: Indications for use Contraceptive oral contraceptives have only two indications for use: protection against unwanted pregnancy (contraception) and functional disorders of the menstrual cycle. Indirect factors in the use of the drug are improving the condition of the skin of the face, eliminating acne and excess oiliness associated with hormonal disruptions. Instructions for use The dosage of tablets is set individually after examination by a gynecologist and testing. Useful information about taking a regular medication: Situation Solution to the problem Skipping the next pill The missing amount of medication must be replenished as soon as possible after the gap is found. If the duration of the delay is less than 12 hours, then the clinical effects of the drug remain, no additional protection is needed. The following pills are taken according to the regimen. Skipping a dose without replenishment within 12 hours It is necessary to take the pill as soon as possible and continue to take it as usual. During the week, you should additionally protect yourself with other non-hormonal methods. If at the time of admission there are less than 7 pieces left in the package, then the next pack should be started without observing a week break. It will come after the end of the second pack of pills. The norm is the appearance of bleeding while taking the second pack. If they have not passed at the end of the package, then consult a doctor. Vomiting, diarrhea during use If in the first 3-4 hours after administration the patient feels vomiting, this indicates incomplete absorption of the drug. You need to proceed as in the case of the pass. Reception to delay or speed up menstruation To delay menstruation, they begin to take a new package without interruption after the first. The stoppage of menstruation can last until the second pack ends. To speed up the onset of menstruation, you can shorten the seven-day break after the first pack by the desired number of days. Lindinet 20 Contraceptive pills are used orally once a day without chewing. They are washed down with water, taken regardless of food intake, preferably at the same time of day. The course lasts 21 days, then a seven-day break is made, and then the course is repeated. During the break, your period will come. It is advisable to start the course on days 1-5 of the menstrual cycle, if no other contraceptives have been taken before. If other hormonal drugs have been taken, the first tablet is taken after taking the last dose of the previously taken drug, on the first day of bleeding after withdrawal. Switching to medication with progestogen-containing drugs requires additional methods of contraception. The first intake of a new contraceptive drug in mini-pill format is performed on any day of the cycle, injections - on the eve of the last, implants - on the next day after removal. Lindinet 30 Another type of drug is prescribed after an abortion for a quick and painless restoration of the hormonal background and the physiological state of a woman. If the abortion was carried out in the first trimester of pregnancy, then you can take the pills immediately after surgery without using additional methods of contraception. If the abortion or childbirth took place in the second trimester, then the use of pills is indicated 21-28 days after the manipulation. In the first week, additional protection is required. Pregnancy and lactation The use of Lindinet birth control pills is contraindicated during pregnancy and lactation (breastfeeding). This is due to the effect of the drug on the hormonal background of the body and possible negative consequences on the development of the fetus. During lactation, hormonal components are excreted in breast milk, which leads to their penetration into the child's body. Side effects While taking the tablets, side effects may occur that require discontinuation of therapy or analysis of its feasibility. These include: arterial hypertension, myocardial infarction, stroke, deep vein thrombosis, pulmonary embolism, venous or arterial thromboembolism of the liver and kidney vessels; hearing loss, otosclerosis; porphyria, exacerbation of lupus erythematosus; acyclic vaginal bleeding, amenorrhea; candidiasis, inflammatory diseases; pain, breast enlargement, galactorrhea; depression, migraines, acute headache; anemia; erythema, skin rash, alopecia, chloasma, pruritus, allergic reactions, Stevens-Johnson syndrome; abdominal pain, nausea, Crohn's disease, vomiting, ulcerative colitis, jaundice, liver adenoma, hepatitis; edema, decreased glucose tolerance, weight gain. Contraindications The contraceptive pill has many contraindications for use. These are: hypersensitivity to the components of the composition; risk of arterial or venous thrombosis; moderate and severe arterial hypertension; angina pectoris, transient ischemic atrial attack; prolonged immobilization after surgery; diabetes; pancreatitis, dyslipidemia, hypertriglyceridemia; hepatitis, cholestatic jaundice, cholelithiasis; hepatic neoplasms; otosclerosis, its history; smoking after 35 years; malignant hormone-dependent tumors (cancer); pregnancy, lactation; epilepsy; vaginal bleeding of unknown origin; age before puberty. Overdose Excessive intake of the tablet preparation is accompanied by nausea, vomiting, smearing or breakthrough non-abundant vaginal bleeding, stomach pain, dizziness. There is no specific antidote for overdose. It is recommended to consult a doctor for the appointment of symptomatic therapy for clinical manifestations of intoxication. special instructions After contraceptive therapy, the effect of contraception gradually fades away. In the first two weeks of taking the pills, it is recommended to adhere to additional contraceptive regimens. To get pregnant after discontinuation of therapy, consult your doctor to find out your health status and perform additional tests. Some experts suggest taking a course of treatment with pills to accelerate conception. Alcohol and Lindinet According to biochemical studies, a small amount of alcohol drunk does not affect the degree of effectiveness of oral contraception with the help of this agent. A moderate dose of ethanol-containing drinks is considered to be up to three glasses of wine or 50 g of brandy or vodka per day. The amount of alcohol above this leads to a decrease in the properties of the drug. Analogs The same medicines based on ethinyl estradiol and gestodene with contraceptive properties can replace the drug. Popular analogs include: Logest is a combined agent with the same concentration of hormones; Femoden is a complete analogue of the drug, produced in dragee format; Angeleta - tablets with ethinyl estradiol and chlormadinone acetate; Vidora is a two-phase preparation of two tablets with drospirenone and ethynyl estradiol; Number of tablets in a package, pcs.	Internet price in rubles	Pharmacy cost in rubles
Lindineth

 

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